![]() For example, patients with severe burn injury as well as cirrhotic patients have been shown to benefit from albumin therapy. Therefore, exogenous albumin is widely used to correct hypoalbuminaemia. Non-survivors of critical illness have lower serum albumin concentrations than survivors. For example, hypoalbuminaemia in hospitalized patients is associated with increased length of stay and higher complication rates. Ī link between low serum albumin and an increase in morbidity and mortality has been shown. It contributes up to 80% of the total colloid osmotic pressure, transports drugs and endogenous compounds, acts as an effective plasma buffer, exhibits significant antioxidant potential, and maintains microvascular integrity. Therefore, low albumin levels, often present in cancer or critically ill patients, might contribute to the frequently occurring venous thromboembolism.Īlbumin, the most abundant plasma protein, has numerous functions in health. Thus, albumin exerted significant anticoagulant action. TEM measurements indicated impaired clot formation in the high albumin group compared with the physiological albumin group. In the low albumin group, when compared to the physiological albumin group, we found: i) shortened PFA 200-derived closure times indicating increased primary haemostasis ii) increased impedance aggregometry-derived amplitudes, slopes, ATP release, as well as CPA-derived average size indicating improved platelet aggregation iii) increased TEM-derived maximum clot firmness and alpha angles indicating enhanced clot formation. Platelet aggregation-associated ATP release was assessed via HPLC analysis. Haemostatic profiling was performed using a platelet function analyzer (PFA) 200, impedance aggregometry, a Cone and Platelet analyzer (CPA), calibrated automated thrombogram, and thrombelastometry (TEM). Whole blood (WB) samples from 25 volunteers were prepared to contain low (19.3 ± 7.7 g/L), physiological (45.2 ± 7.8 g/L), and high (67.5 ± 18.1 g/L) levels of albumin. This study aimed to track the concentration-dependent influence of albumin on blood coagulation in vitro. This hypoalbuminaemia is usually corrected by administration of exogenous albumin. ![]() Critical illness is often associated with altered, predominately decreased, serum albumin levels. Albumin is the most abundant plasma protein. ![]()
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